NOTCH2NL

Entrez Summary: N/A
UniProt Summary: May function in the Notch signaling pathway and regulate neutrophil differentiation. {ECO:0000269|PubMed:14673143}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	-2.31
CFI-400945 25μM R08 exp469	-2.18
Nocodazole 0.2μM R00 exp24	-2.01
LB-100 2μM R05 exp210	-1.86
MLN-4924 2μM R00 exp22	-1.73
JQ1 0.8μM R08 exp435	-1.71
Vinblastine 0.015μM R05 exp208	-1.71
Dynasore 7μM R08 exp436	1.77
IU1-C 25μM R04 exp183	1.78
Ethambutol 25μM R08 exp481	1.8
D-Fructose 10000μM R06 exp279	1.9
Rapamycin 0.001μM R08 exp429	2
NN-Dimethylsphingosine 2.5μM R08 exp508	2.11
BH1 1μM R04 exp169	2.19
Heregulin-B 44ng/ml R08 exp486	2.19
Isoniazid 100μM R08 exp494	2.35
Pyrazinamide 100μM R08 exp516	2.45

Expression Distribution

EGF
EGF CA

Notch binding
positive regulation of Notch signaling pathway
regulation of Notch signaling pathway
cerebral cortex development
Notch signaling pathway
pallium development
telencephalon development
forebrain development
calcium ion binding
brain development
head development
central nervous system development
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
extracellular region