NOTO

Entrez Summary: N/A
UniProt Summary: Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
notochord development
motile cilium assembly
heart looping
embryonic pattern specification
determination of heart left/right asymmetry
embryonic heart tube morphogenesis
embryonic heart tube development
regulation of cilium assembly
dorsal/ventral pattern formation
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
DNA-binding transcription repressor activity, RNA polymerase II-specific
heart morphogenesis
embryonic organ morphogenesis
epithelial tube morphogenesis
regionalization
cilium assembly
cilium organization
morphogenesis of an epithelium
embryonic organ development
pattern specification process
plasma membrane bounded cell projection assembly
cell projection assembly
RNA polymerase II proximal promoter sequence-specific DNA binding
heart development
tissue morphogenesis
embryonic morphogenesis
tube morphogenesis
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
organelle assembly
tube development
circulatory system development
animal organ morphogenesis
regulation of cellular component biogenesis