NOX1

Gene Information

Official Symbol: NOX1
Official Name: N/ADPH oxidase 1
Aliases and Previous Symbols: N/A
Entrez ID: 27035
UniProt: Q9Y5S8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012].
UniProt Summary: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7161
Expression level (log2 read counts): 0.0

Expression Distribution

Ferric reduct
NAD binding 6
FAD binding 8

cellular stress response to acidic pH
oxygen metabolic process
positive regulation of integrin biosynthetic process
regulation of integrin biosynthetic process
invadopodium membrane
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
intracellular pH elevation
cellular response to hyperoxia
pH elevation
superoxide-generating NADPH oxidase activity
cellular response to acidic pH
cellular response to increased oxygen levels
NADPH oxidase complex
regulation of plasma membrane organization
positive regulation of oxidative stress-induced cell death
superoxide anion generation
positive regulation of cellular response to oxidative stress
positive regulation of response to oxidative stress
respiratory burst
response to hyperoxia
regulation of systemic arterial blood pressure by renin-angiotensin
cellular response to pH
response to acidic pH
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of vascular endothelial growth factor production
response to increased oxygen levels
NADP metabolic process
regulation of vascular endothelial growth factor production
regulation of systemic arterial blood pressure by hormone
NADP binding
hydrogen peroxide metabolic process
superoxide metabolic process
response to pH
voltage-gated ion channel activity
regulation of systemic arterial blood pressure mediated by a chemical signal
endocrine process
Rac GTPase binding
positive regulation of intrinsic apoptotic signaling pathway
regulation of oxidative stress-induced cell death
regulation of cellular response to oxidative stress