NOX5 [The Human Chemical-Genetic Interaction Map Project]

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======= NOX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOX5
  * **<color #00a2e8>Official Name</color>**: N/ADPH oxidase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79400|79400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PH1|Q96PH1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606572|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ferric reduct|
|NAD binding 6|
|FAD binding 8|
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of fusion of sperm to egg plasma membrane|
|proton channel activity|
|superoxide-generating NADPH oxidase activity|
|NADPH oxidase complex|
|superoxide anion generation|
|regulation of proton transport|
|endothelial cell proliferation|
|regulation of fertilization|
|NADP binding|
|superoxide metabolic process|
|cytokine secretion|
|flavin adenine dinucleotide binding|
|epithelial cell proliferation|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|reactive oxygen species metabolic process|
|heme binding|
|proton transmembrane transport|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of reproductive process|
|protein localization to extracellular region|
|peptide secretion|
|cellular response to oxidative stress|
|angiogenesis|
|regulation of cation transmembrane transport|
|response to oxidative stress|
|monovalent inorganic cation transport|
|blood vessel morphogenesis|
|regulation of ion transmembrane transport|
|blood vessel development|
|cell division|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|tube morphogenesis|
|regulation of ion transport|
|calcium ion binding|
|regulation of multi-organism process|
|cation transport|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|oxidation-reduction process|
|cell cycle process|
|secretion by cell|
|export from cell|
|programmed cell death|
|cell death|
|secretion|
|transmembrane transport|
|defense response|
|cell cycle|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|cellular response to stress|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.538|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8984
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOX5 Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>