NOX5

Entrez Summary: This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of fusion of sperm to egg plasma membrane
proton channel activity
superoxide-generating NADPH oxidase activity
NADPH oxidase complex
superoxide anion generation
regulation of proton transport
endothelial cell proliferation
regulation of fertilization
NADP binding
superoxide metabolic process
cytokine secretion
flavin adenine dinucleotide binding
epithelial cell proliferation
cytoskeleton-dependent cytokinesis
cytokinesis
reactive oxygen species metabolic process
heme binding
proton transmembrane transport
cytokine production
protein secretion
establishment of protein localization to extracellular region
regulation of reproductive process
protein localization to extracellular region
peptide secretion
cellular response to oxidative stress
angiogenesis
regulation of cation transmembrane transport
response to oxidative stress
monovalent inorganic cation transport
blood vessel morphogenesis
regulation of ion transmembrane transport
blood vessel development
cell division
vasculature development
cardiovascular system development
cell population proliferation
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport