NPHP3

Entrez Summary: This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin, it is required for normal ciliary development, and it functions in renal tubular development. Mutations in this gene are associated with nephronophthisis type 3, and also with renal-hepatic-pancreatic dysplasia, and Meckel syndrome type 7. Naturally occurring read-through transcripts exist between this gene and the downstream ACAD11 (acyl-CoA dehydrogenase family, member 11) gene. [provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of planar cell polarity pathway involved in neural tube closure
determination of intestine left/right asymmetry
determination of stomach left/right asymmetry
stomach development
maintenance of animal organ identity
determination of pancreatic left/right asymmetry
determination of liver left/right asymmetry
determination of digestive tract left/right asymmetry
convergent extension involved in gastrulation
epithelial cilium movement involved in determination of left/right asymmetry
convergent extension
regulation of establishment of planar polarity involved in neural tube closure
regulation of Wnt signaling pathway, planar cell polarity pathway
ureter development
regulation of epithelial tube formation
atrial septum development
regulation of non-canonical Wnt signaling pathway
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
cardiac atrium development
photoreceptor cell maintenance
cilium movement
heart looping
determination of heart left/right asymmetry
embryonic heart tube morphogenesis
pancreas development
retina homeostasis
embryonic heart tube development
kidney morphogenesis
cardiac septum development
regulation of establishment of planar polarity
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
liver development
hepaticobiliary system development
regulation of embryonic development
digestive tract development
digestive system development
gastrulation