NPNT

Gene Information

Official Symbol: NPNT
Official Name: nephronectin
Aliases and Previous Symbols: N/A
Entrez ID: 255743
UniProt: Q6UXI9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8494
Expression level (log2 read counts): -2.84

Expression Distribution

EGF CA
EGF 3
MAM
cEGF

positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
pilomotor reflex
integrin alpha8-beta1 complex
smooth muscle contractile fiber
cell-cell adhesion mediated by integrin
positive regulation of alkaline phosphatase activity
regulation of alkaline phosphatase activity
reflex
cell adhesion mediated by integrin
positive regulation of cellular response to transforming growth factor beta stimulus
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of smooth muscle contraction
smooth muscle cell differentiation
positive regulation of phosphatase activity
branching involved in ureteric bud morphogenesis
positive regulation of muscle contraction
ureteric bud morphogenesis
mesonephric tubule morphogenesis
positive regulation of dephosphorylation
positive regulation of osteoblast differentiation
regulation of smooth muscle contraction
nephron tubule morphogenesis
nephron epithelium morphogenesis
nephron morphogenesis
renal tubule morphogenesis
nephron tubule development
renal tubule development
kidney morphogenesis
positive regulation of ossification
ureteric bud development
mesonephric epithelium development
mesonephric tubule development
basement membrane
mesonephros development
nephron epithelium development
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of osteoblast differentiation
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
positive regulation of cell-substrate adhesion