NPTX1

Entrez Summary: N/A
UniProt Summary: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

axonogenesis involved in innervation
regulation of postsynaptic neurotransmitter receptor activity
innervation
regulation of neurotransmitter receptor activity
nerve development
transport vesicle
regulation of nervous system process
regulation of signaling receptor activity
neuron projection
glutamatergic synapse
axonogenesis
axon development
chemical synaptic transmission
anterograde trans-synaptic signaling
cell morphogenesis involved in neuron differentiation
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
synaptic signaling
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
cell morphogenesis involved in differentiation
regulation of system process
neuron projection development
cell morphogenesis
neuron development
cellular component morphogenesis
central nervous system development
neuron differentiation
cell-cell signaling
plasma membrane bounded cell projection organization
cell projection organization
generation of neurons
neurogenesis
cell development