NPY

Entrez Summary: This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014].
UniProt Summary: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neuropeptide Y receptor binding
positive regulation of appetite
positive regulation of response to food
positive regulation of response to extracellular stimulus
positive regulation of response to nutrient levels
adult feeding behavior
regulation of response to food
intestinal epithelial cell differentiation
regulation of appetite
regulation of response to extracellular stimulus
regulation of response to nutrient levels
neuropeptide hormone activity
calcium channel regulator activity
G protein-coupled receptor binding
central nervous system neuron development
cell
feeding behavior
columnar/cuboidal epithelial cell differentiation
neuropeptide signaling pathway
cerebral cortex development
digestive tract development
digestive system development
adult behavior
pallium development
central nervous system neuron differentiation
regulation of blood pressure
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
telencephalon development
signaling receptor binding
forebrain development
blood circulation
circulatory system process
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
response to nutrient levels
response to extracellular stimulus
behavior
positive regulation of response to external stimulus