NPY2R
Gene Information
- Official Symbol: NPY2R
- Official Name: neuropeptide Y receptor Y2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4887
- UniProt: P49146
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
| 7TM GPCR Srsx |
GO Terms
| peptide YY receptor activity |
| positive regulation of circadian sleep/wake cycle, non-REM sleep |
| positive regulation of circadian sleep/wake cycle, sleep |
| positive regulation of dopamine secretion |
| regulation of circadian sleep/wake cycle, non-REM sleep |
| negative regulation of synaptic transmission, glutamatergic |
| negative regulation of feeding behavior |
| neuropeptide Y receptor activity |
| negative regulation of excitatory postsynaptic potential |
| positive regulation of catecholamine secretion |
| cardiac left ventricle morphogenesis |
| positive regulation of circadian rhythm |
| negative regulation of behavior |
| regulation of circadian sleep/wake cycle, sleep |
| nitric oxide mediated signal transduction |
| regulation of circadian sleep/wake cycle |
| negative regulation of cAMP-mediated signaling |
| negative regulation of nervous system process |
| positive regulation of behavior |
| regulation of feeding behavior |
| behavioral fear response |
| positive regulation of response to drug |
| behavioral defense response |
| positive regulation of smooth muscle contraction |
| non-motile cilium |
| fear response |
| positive regulation of amine transport |
| calcium channel regulator activity |
| regulation of sensory perception of pain |
| modulation of excitatory postsynaptic potential |
| regulation of dopamine secretion |
| regulation of sensory perception |
| positive regulation of muscle contraction |
| regulation of cAMP-mediated signaling |
| regulation of smooth muscle contraction |
| negative regulation of synaptic transmission |
| regulation of catecholamine secretion |
| multicellular organismal response to stress |
| regulation of synaptic transmission, glutamatergic |
| regulation of behavior |
| cardiac ventricle morphogenesis |
| outflow tract morphogenesis |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| regulation of amine transport |
| regulation of response to drug |
| neuropeptide signaling pathway |
| regulation of circadian rhythm |
| positive regulation of cell-substrate adhesion |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| regulation of nervous system process |
| regulation of muscle contraction |
| cardiac chamber development |
| locomotory behavior |
| cilium |
| signaling receptor activity |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of cell-substrate adhesion |
| negative regulation of secretion |
| regulation of muscle system process |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| heart morphogenesis |
| positive regulation of ion transport |
| aging |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of peptide secretion |
| regulation of cytosolic calcium ion concentration |
| second-messenger-mediated signaling |
| positive regulation of secretion by cell |
| positive regulation of cell adhesion |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| heart development |
| cellular metal ion homeostasis |
| behavior |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| regulation of cell adhesion |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| circulatory system development |
| cellular homeostasis |
| animal organ morphogenesis |
| positive regulation of transport |
| chemical homeostasis |
| secretion |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| negative regulation of response to stimulus |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of intracellular signal transduction |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CFI-400945 25μM R08 exp469 | -1.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12136
- Expression level (log2 read counts): -7.68
Expression Distribution
NPY2R Expression in NALM6 Cells: -7.68
