NQO2

Entrez Summary: This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
UniProt Summary: The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Flavodoxin 2
FMN red

melatonin binding
resveratrol binding
dihydronicotinamide riboside quinone reductase activity
oxidoreductase activity, acting on other nitrogenous compounds as donors
NAD(P)H dehydrogenase (quinone) activity
chloride ion binding
FAD binding
positive regulation of vascular smooth muscle cell proliferation
regulation of vascular smooth muscle cell proliferation
positive regulation of neuron apoptotic process
electron transfer activity
positive regulation of smooth muscle cell proliferation
positive regulation of neuron death
positive regulation of reactive oxygen species metabolic process
memory
oxidoreductase activity
xenobiotic metabolic process
regulation of smooth muscle cell proliferation
regulation of reactive oxygen species metabolic process
electron transport chain
cellular response to xenobiotic stimulus
regulation of neuron apoptotic process
positive regulation of ERK1 and ERK2 cascade
learning or memory
regulation of ERK1 and ERK2 cascade
cognition
response to xenobiotic stimulus
regulation of neuron death
generation of precursor metabolites and energy
positive regulation of MAPK cascade
behavior
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of MAPK cascade
zinc ion binding
protein homodimerization activity
positive regulation of cell population proliferation
oxidation-reduction process
positive regulation of protein phosphorylation