NR2F2 [The Human Chemical-Genetic Interaction Map Project]

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======= NR2F2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR2F2
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 2 group F member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7026|7026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P24468|P24468]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR2F2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR2F2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107773|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. {ECO:0000269|PubMed:18798693, ECO:0000269|PubMed:1899293, ECO:0000269|PubMed:9343308}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|radial pattern formation|
|regulation of transcription involved in lymphatic endothelial cell fate commitment|
|lymphatic endothelial cell fate commitment|
|endothelial cell fate commitment|
|lymphatic endothelial cell differentiation|
|trophoblast giant cell differentiation|
|positive regulation of systemic arterial blood pressure|
|epithelial cell fate commitment|
|regulation of transcription involved in cell fate commitment|
|lymph vessel development|
|retinoic acid binding|
|cell differentiation involved in embryonic placenta development|
|negative regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of cyclin-dependent protein kinase activity|
|placenta blood vessel development|
|maternal placenta development|
|negative regulation of endothelial cell proliferation|
|positive regulation of blood pressure|
|nuclear receptor activity|
|negative regulation of endothelial cell migration|
|steroid hormone receptor activity|
|maternal process involved in female pregnancy|
|negative regulation of epithelial cell migration|
|endothelial cell differentiation|
|embryonic placenta development|
|regulation of systemic arterial blood pressure|
|endothelium development|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|steroid hormone mediated signaling pathway|
|neuron migration|
|skeletal muscle tissue development|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|skeletal muscle organ development|
|negative regulation of protein serine/threonine kinase activity|
|response to estradiol|
|placenta development|
|regulation of endothelial cell migration|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|fertilization|
|limb development|
|appendage development|
|female pregnancy|
|regulation of blood pressure|
|cellular response to steroid hormone stimulus|
|multi-multicellular organism process|
|anterior/posterior pattern specification|
|regulation of epithelial cell migration|
|negative regulation of protein kinase activity|
|transcription corepressor activity|
|negative regulation of kinase activity|
|cell fate commitment|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of transferase activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|negative regulation of cellular component movement|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of locomotion|
|response to steroid hormone|
|regionalization|
|regulation of epithelial cell proliferation|
|in utero embryonic development|
|forebrain development|
|blood circulation|
|circulatory system process|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|pattern specification process|
|negative regulation of phosphorylation|
|muscle structure development|
|blood vessel development|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|brain development|
|head development|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|cell migration|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|multi-organism reproductive process|
|regulation of cellular component movement|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12762
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR2F2 Expression in NALM6 Cells: -2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>