NR2F2
Gene Information
- Official Symbol: NR2F2
- Official Name: nuclear receptor subfamily 2 group F member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7026
- UniProt: P24468
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
- UniProt Summary: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. {ECO:0000269|PubMed:18798693, ECO:0000269|PubMed:1899293, ECO:0000269|PubMed:9343308}.
Pfam Domains GO Terms
Pfam Domains
| zf-C4 |
| Hormone recep |
GO Terms
| radial pattern formation |
| regulation of transcription involved in lymphatic endothelial cell fate commitment |
| lymphatic endothelial cell fate commitment |
| endothelial cell fate commitment |
| lymphatic endothelial cell differentiation |
| trophoblast giant cell differentiation |
| positive regulation of systemic arterial blood pressure |
| epithelial cell fate commitment |
| regulation of transcription involved in cell fate commitment |
| lymph vessel development |
| retinoic acid binding |
| cell differentiation involved in embryonic placenta development |
| negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of cyclin-dependent protein kinase activity |
| placenta blood vessel development |
| maternal placenta development |
| negative regulation of endothelial cell proliferation |
| positive regulation of blood pressure |
| nuclear receptor activity |
| negative regulation of endothelial cell migration |
| steroid hormone receptor activity |
| maternal process involved in female pregnancy |
| negative regulation of epithelial cell migration |
| endothelial cell differentiation |
| embryonic placenta development |
| regulation of systemic arterial blood pressure |
| endothelium development |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of cyclin-dependent protein kinase activity |
| steroid hormone mediated signaling pathway |
| neuron migration |
| skeletal muscle tissue development |
| negative regulation of epithelial cell proliferation |
| regulation of endothelial cell proliferation |
| skeletal muscle organ development |
| negative regulation of protein serine/threonine kinase activity |
| response to estradiol |
| placenta development |
| regulation of endothelial cell migration |
| intracellular receptor signaling pathway |
| hormone-mediated signaling pathway |
| fertilization |
| limb development |
| appendage development |
| female pregnancy |
| regulation of blood pressure |
| cellular response to steroid hormone stimulus |
| multi-multicellular organism process |
| anterior/posterior pattern specification |
| regulation of epithelial cell migration |
| negative regulation of protein kinase activity |
| transcription corepressor activity |
| negative regulation of kinase activity |
| cell fate commitment |
| negative regulation of cell migration |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| negative regulation of cellular component movement |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| negative regulation of locomotion |
| response to steroid hormone |
| regionalization |
| regulation of epithelial cell proliferation |
| in utero embryonic development |
| forebrain development |
| blood circulation |
| circulatory system process |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| sequence-specific DNA binding |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| pattern specification process |
| negative regulation of phosphorylation |
| muscle structure development |
| blood vessel development |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| cellular response to lipid |
| cellular response to organic cyclic compound |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| cellular response to hormone stimulus |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| brain development |
| head development |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| zinc ion binding |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| protein homodimerization activity |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| cell migration |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| multi-organism reproductive process |
| regulation of cellular component movement |
| negative regulation of cellular protein metabolic process |
| localization of cell |
| cell motility |
| negative regulation of protein metabolic process |
| epithelium development |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Epigallocatechin gallate 20μM R05 exp230 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12762
- Expression level (log2 read counts): -2.28
Expression Distribution
NR2F2 Expression in NALM6 Cells: -2.28
