NR5A2

Entrez Summary: The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016].
UniProt Summary: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Hormone recep
zf-C4

pancreas morphogenesis
calcineurin-mediated signaling
positive regulation of viral genome replication
bile acid metabolic process
nuclear receptor activity
steroid hormone receptor activity
positive regulation of viral life cycle
RNA polymerase II transcription factor complex
pancreas development
transcription regulatory region sequence-specific DNA binding
cholesterol homeostasis
sterol homeostasis
regulation of viral genome replication
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
RNA polymerase II distal enhancer sequence-specific DNA binding
phospholipid binding
positive regulation of viral process
steroid hormone mediated signaling pathway
lipid homeostasis
regulation of viral life cycle
calcium-mediated signaling
intracellular receptor signaling pathway
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
cellular response to steroid hormone stimulus
regulation of viral process
DNA-templated transcription, initiation
transcription regulatory region DNA binding
regulation of symbiosis, encompassing mutualism through parasitism
steroid metabolic process
response to steroid hormone
second-messenger-mediated signaling
chromatin binding
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
organic hydroxy compound metabolic process
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of multi-organism process