NRAP [The Human Chemical-Genetic Interaction Map Project]

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======= NRAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRAP
  * **<color #00a2e8>Official Name</color>**: nebulin related anchoring protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4892|4892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VF7|Q86VF7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602873|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nebulin|
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle tendon junction|
|cardiac muscle thin filament assembly|
|fascia adherens|
|muscle alpha-actinin binding|
|cardiac myofibril assembly|
|muscle fiber development|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle cell differentiation|
|cellular component assembly involved in morphogenesis|
|actomyosin structure organization|
|cardiocyte differentiation|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|cardiac muscle tissue development|
|striated muscle cell differentiation|
|actin filament binding|
|actin filament organization|
|muscle cell differentiation|
|actin binding|
|striated muscle tissue development|
|muscle tissue development|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|actin filament-based process|
|organelle assembly|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cytoskeleton organization|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.5|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.75|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.76|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.77|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.83|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.9|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.91|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.03|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6356
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRAP Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>