NRAP

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.5
TRAIL 5ng/ml R00 exp35	1.75
Doxycycline 10μM R00 exp18	1.76
Celastrol 0.12μM R05 exp225	1.77
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.83
Campthothecin 0.001μM R06 exp270	1.9
Bisphenol F 50μM R08 exp457	1.91
Phenformin 20μM R05 exp212	2.03
Monensin 0.3μM R08 exp507	2.11

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Nebulin
LIM

muscle tendon junction
cardiac muscle thin filament assembly
fascia adherens
muscle alpha-actinin binding
cardiac myofibril assembly
muscle fiber development
cardiac muscle cell development
cardiac cell development
myofibril assembly
cardiac muscle cell differentiation
cellular component assembly involved in morphogenesis
actomyosin structure organization
cardiocyte differentiation
Z disc
striated muscle cell development
muscle cell development
cardiac muscle tissue development
striated muscle cell differentiation
actin filament binding
actin filament organization
muscle cell differentiation
actin binding
striated muscle tissue development
muscle tissue development
supramolecular fiber organization
muscle structure development
actin cytoskeleton organization
heart development
actin filament-based process
organelle assembly
cellular component morphogenesis
circulatory system development
anatomical structure formation involved in morphogenesis
cytoskeleton organization
cell development
tissue development