NRAS [The Human Chemical-Genetic Interaction Map Project]

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======= NRAS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRAS
  * **<color #00a2e8>Official Name</color>**: NRAS proto-oncogene, GTPase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4893|4893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01111|P01111]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRAS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRAS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164790|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Arf|
|Miro|
|GTP EFTU|
|Ras|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tertiary granule membrane|
|GDP binding|
|positive regulation of endothelial cell proliferation|
|stimulatory C-type lectin receptor signaling pathway|
|innate immune response activating cell surface receptor signaling pathway|
|regulation of endothelial cell proliferation|
|positive regulation of epithelial cell proliferation|
|innate immune response-activating signal transduction|
|Ras protein signal transduction|
|activation of innate immune response|
|protein-containing complex binding|
|small GTPase mediated signal transduction|
|GTPase activity|
|regulation of epithelial cell proliferation|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|GTP binding|
|signal transduction by protein phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|regulation of innate immune response|
|positive regulation of defense response|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|myeloid cell activation involved in immune response|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulated exocytosis|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|leukocyte activation|
|protein phosphorylation|
|Golgi apparatus|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|phosphorylation|
|regulation of response to stress|
|regulation of cell population proliferation|
|regulation of immune system process|
|intracellular signal transduction|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-3.85|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-3.41|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-3.39|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-3.25|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-3.23|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-3.06|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.98|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.86|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.77|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.65|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.4|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.39|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.18|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.05|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.96|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.81|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.8|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.8|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.75|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.74|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.7|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.9|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.2|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.59|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|6.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:shoc2|SHOC2]]|0.609|
|[[:human genes:r:raf1|RAF1]]|0.594|
|[[:human genes:m:mapk1|MAPK1]]|0.551|
|[[:human genes:p:prkce|PRKCE]]|0.544|
|[[:human genes:b:braf|BRAF]]|0.509|
|[[:human genes:s:scrib|SCRIB]]|0.432|
|[[:human genes:e:ergic1|ERGIC1]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 33/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|5/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1276
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRAS Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>