NRAS

• Official Symbol: NRAS
• Official Name: NRAS proto-oncogene, GTPase
• Aliases and Previous Symbols: N/A
• Entrez ID: 4893
• UniProt: P01111
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011].
• UniProt Summary: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 1276
• Expression level (log2 read counts): 6.73

Expression Distribution

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NRAS Expression in NALM6 Cells: 6.73