NRDE2 [The Human Chemical-Genetic Interaction Map Project]

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======= NRDE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRDE2
  * **<color #00a2e8>Official Name</color>**: NRDE-2, necessary for RNA interference, domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55051|55051]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7Z3|Q9H7Z3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRDE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRDE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618631|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1740|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin silencing by small RNA|
|RNA interference|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|gene silencing by RNA|
|gene silencing|
|regulation of gene expression, epigenetic|
|cellular component|
|posttranscriptional regulation of gene expression|
|chromatin organization|
|molecular function|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.52|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.35|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.16|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.04|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.94|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.92|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.91|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.85|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.81|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.79|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.79|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|1.75|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.75|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.78|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.81|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.91|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.94|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 568/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|20/28|
|bone|22/26|
|breast|23/33|
|central nervous system|46/56|
|cervix|2/4|
|colorectal|13/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|11/16|
|kidney|20/21|
|liver|15/20|
|lung|52/75|
|lymphocyte|12/16|
|ovary|20/26|
|pancreas|16/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|9/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|18/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 635
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRDE2 Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>