NRDE2

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 568/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	20/28
bone	22/26
breast	23/33
central nervous system	46/56
cervix	2/4
colorectal	13/17
esophagus	7/13
fibroblast	1/1
gastric	11/16
kidney	20/21
liver	15/20
lung	52/75
lymphocyte	12/16
ovary	20/26
pancreas	16/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	0/1
skin	19/24
soft tissue	9/9
thyroid	1/2
upper aerodigestive	14/22
urinary tract	18/29
uterus	5/5

Expression Distribution

chromatin silencing by small RNA
RNA interference
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
chromatin organization involved in negative regulation of transcription
chromatin silencing
chromatin organization involved in regulation of transcription
negative regulation of gene expression, epigenetic
gene silencing by RNA
gene silencing
regulation of gene expression, epigenetic
cellular component
posttranscriptional regulation of gene expression
chromatin organization
molecular function
chromosome organization
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of gene expression