NRGN

Entrez Summary: N/A
UniProt Summary: Acts as a “third messenger” substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

trans-Golgi network transport vesicle membrane
dendritic spine head
postsynaptic modulation of chemical synaptic transmission
phosphatidic acid binding
positive regulation of long-term synaptic potentiation
phosphatidylinositol-3,4,5-trisphosphate binding
regulation of long-term synaptic potentiation
associative learning
mitochondrial membrane
learning
positive regulation of synaptic transmission
regulation of synaptic plasticity
postsynaptic membrane
calmodulin binding
postsynaptic density
telencephalon development
learning or memory
axon
cognition
glutamatergic synapse
neuronal cell body
forebrain development
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
behavior
brain development
head development
central nervous system development
nervous system process
positive regulation of cell communication
positive regulation of signaling
system process