NRP2 [The Human Chemical-Genetic Interaction Map Project]

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======= NRP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRP2
  * **<color #00a2e8>Official Name</color>**: neuropilin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8828|8828]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60462|O60462]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F5 F8 type C|
|MAM|
|DUF3481|
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ganglion morphogenesis|
|dorsal root ganglion morphogenesis|
|vestibulocochlear nerve structural organization|
|facioacoustic ganglion development|
|hypothalamic tangential migration using cell-axon interactions|
|cerebral cortex tangential migration using cell-axon interactions|
|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|
|sensory neuron axon guidance|
|sympathetic neuron projection extension|
|hypothalamus gonadotrophin-releasing hormone neuron development|
|hypothalamus gonadotrophin-releasing hormone neuron differentiation|
|ventral trunk neural crest cell migration|
|trunk neural crest cell migration|
|hypothalamus cell migration|
|trunk segmentation|
|sympathetic neuron projection guidance|
|trigeminal ganglion development|
|substrate-dependent cerebral cortex tangential migration|
|neural crest cell migration involved in autonomic nervous system development|
|cranial ganglion development|
|vascular endothelial growth factor-activated receptor activity|
|dorsal root ganglion development|
|vestibulocochlear nerve morphogenesis|
|neuron projection extension involved in neuron projection guidance|
|axon extension involved in axon guidance|
|hypothalamus cell differentiation|
|cerebral cortex tangential migration|
|sympathetic ganglion development|
|facial nerve structural organization|
|vestibulocochlear nerve development|
|semaphorin receptor complex|
|facial nerve morphogenesis|
|facial nerve development|
|cranial nerve structural organization|
|semaphorin receptor activity|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|ganglion development|
|anatomical structure arrangement|
|preganglionic parasympathetic fiber development|
|blastoderm segmentation|
|parasympathetic nervous system development|
|vascular endothelial growth factor signaling pathway|
|sympathetic nervous system development|
|hypothalamus development|
|substrate-dependent cell migration|
|outflow tract septum morphogenesis|
|cranial nerve morphogenesis|
|forebrain neuron development|
|growth factor binding|
|axon extension|
|semaphorin-plexin signaling pathway|
|cellular response to vascular endothelial growth factor stimulus|
|cytokine binding|
|cerebral cortex cell migration|
|integral component of postsynaptic membrane|
|autonomic nervous system development|
|negative chemotaxis|
|forebrain neuron differentiation|
|cranial nerve development|
|neural crest cell migration|
|telencephalon cell migration|
|neuron projection extension|
|forebrain cell migration|
|embryonic pattern specification|
|forebrain generation of neurons|
|vascular endothelial growth factor receptor signaling pathway|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|diencephalon development|
|neural crest cell development|
|nerve development|
|central nervous system neuron development|
|stem cell development|
|mesenchymal cell development|
|developmental cell growth|
|neural crest cell differentiation|
|cell growth|
|positive regulation of endothelial cell proliferation|
|segmentation|
|regulation of postsynapse organization|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|positive regulation of endothelial cell migration|
|limbic system development|
|cardiac septum development|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|neuron migration|
|cardiac chamber morphogenesis|
|regulation of endothelial cell proliferation|
|positive regulation of epithelial cell migration|
|mesenchymal cell differentiation|
|regulation of endothelial cell migration|
|stem cell differentiation|
|cardiac chamber development|
|heparin binding|
|ameboidal-type cell migration|
|pallium development|
|central nervous system neuron differentiation|
|positive regulation of epithelial cell proliferation|
|signaling receptor activity|
|regulation of synapse organization|
|regulation of epithelial cell migration|
|mesenchyme development|
|regulation of synapse structure or activity|
|heart morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|axon|
|angiogenesis|
|regionalization|
|regulation of epithelial cell proliferation|
|glutamatergic synapse|
|axonogenesis|
|forebrain development|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|tube morphogenesis|
|neuron projection development|
|viral process|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|head development|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|cell motility|
|localization of cell|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.38|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.92|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.86|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.79|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.71|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9789
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRP2 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>