NRP2
Gene Information
- Official Symbol: NRP2
- Official Name: neuropilin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8828
- UniProt: O60462
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| F5 F8 type C |
| MAM |
| DUF3481 |
| CUB |
GO Terms
| ganglion morphogenesis |
| dorsal root ganglion morphogenesis |
| vestibulocochlear nerve structural organization |
| facioacoustic ganglion development |
| hypothalamic tangential migration using cell-axon interactions |
| cerebral cortex tangential migration using cell-axon interactions |
| gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
| sensory neuron axon guidance |
| sympathetic neuron projection extension |
| hypothalamus gonadotrophin-releasing hormone neuron development |
| hypothalamus gonadotrophin-releasing hormone neuron differentiation |
| ventral trunk neural crest cell migration |
| trunk neural crest cell migration |
| hypothalamus cell migration |
| trunk segmentation |
| sympathetic neuron projection guidance |
| trigeminal ganglion development |
| substrate-dependent cerebral cortex tangential migration |
| neural crest cell migration involved in autonomic nervous system development |
| cranial ganglion development |
| vascular endothelial growth factor-activated receptor activity |
| dorsal root ganglion development |
| vestibulocochlear nerve morphogenesis |
| neuron projection extension involved in neuron projection guidance |
| axon extension involved in axon guidance |
| hypothalamus cell differentiation |
| cerebral cortex tangential migration |
| sympathetic ganglion development |
| facial nerve structural organization |
| vestibulocochlear nerve development |
| semaphorin receptor complex |
| facial nerve morphogenesis |
| facial nerve development |
| cranial nerve structural organization |
| semaphorin receptor activity |
| semaphorin-plexin signaling pathway involved in neuron projection guidance |
| ganglion development |
| anatomical structure arrangement |
| preganglionic parasympathetic fiber development |
| blastoderm segmentation |
| parasympathetic nervous system development |
| vascular endothelial growth factor signaling pathway |
| sympathetic nervous system development |
| hypothalamus development |
| substrate-dependent cell migration |
| outflow tract septum morphogenesis |
| cranial nerve morphogenesis |
| forebrain neuron development |
| growth factor binding |
| axon extension |
| semaphorin-plexin signaling pathway |
| cellular response to vascular endothelial growth factor stimulus |
| cytokine binding |
| cerebral cortex cell migration |
| integral component of postsynaptic membrane |
| autonomic nervous system development |
| negative chemotaxis |
| forebrain neuron differentiation |
| cranial nerve development |
| neural crest cell migration |
| telencephalon cell migration |
| neuron projection extension |
| forebrain cell migration |
| embryonic pattern specification |
| forebrain generation of neurons |
| vascular endothelial growth factor receptor signaling pathway |
| cardiac septum morphogenesis |
| outflow tract morphogenesis |
| diencephalon development |
| neural crest cell development |
| nerve development |
| central nervous system neuron development |
| stem cell development |
| mesenchymal cell development |
| developmental cell growth |
| neural crest cell differentiation |
| cell growth |
| positive regulation of endothelial cell proliferation |
| segmentation |
| regulation of postsynapse organization |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| positive regulation of endothelial cell migration |
| limbic system development |
| cardiac septum development |
| developmental growth involved in morphogenesis |
| cerebral cortex development |
| neuron migration |
| cardiac chamber morphogenesis |
| regulation of endothelial cell proliferation |
| positive regulation of epithelial cell migration |
| mesenchymal cell differentiation |
| regulation of endothelial cell migration |
| stem cell differentiation |
| cardiac chamber development |
| heparin binding |
| ameboidal-type cell migration |
| pallium development |
| central nervous system neuron differentiation |
| positive regulation of epithelial cell proliferation |
| signaling receptor activity |
| regulation of synapse organization |
| regulation of epithelial cell migration |
| mesenchyme development |
| regulation of synapse structure or activity |
| heart morphogenesis |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| axon |
| angiogenesis |
| regionalization |
| regulation of epithelial cell proliferation |
| glutamatergic synapse |
| axonogenesis |
| forebrain development |
| developmental growth |
| growth |
| blood vessel morphogenesis |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| pattern specification process |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| cell part morphogenesis |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| tube morphogenesis |
| neuron projection development |
| viral process |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| head development |
| symbiotic process |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| cell migration |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| neuron differentiation |
| cell motility |
| localization of cell |
| response to cytokine |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| locomotion |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| tissue development |
| extracellular region |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN 20μM R00 exp17 | -2.38 |
| FK-506 5μM R07 exp358 | -1.92 |
| Geldanamycin 0.015 to 0.025μM on day4 R07 exp316 | -1.86 |
| Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307 | -1.79 |
| S-DABN 8μM R03 exp112 | -1.71 |
| Chloroquine 32μM R08 exp470 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9789
- Expression level (log2 read counts): 2.89
Expression Distribution
NRP2 Expression in NALM6 Cells: 2.89
