NRROS [The Human Chemical-Genetic Interaction Map Project]

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======= NRROS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NRROS
  * **<color #00a2e8>Official Name</color>**: negative regulator of reactive oxygen species
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=375387|375387]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YC3|Q86YC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NRROS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NRROS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615322|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. {ECO:0000250, ECO:0000269|PubMed:23545260}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transforming growth factor beta1 activation|
|transforming growth factor beta1 production|
|transforming growth factor beta production|
|transforming growth factor beta activation|
|microglia differentiation|
|sequestering of TGFbeta in extracellular matrix|
|microglia development|
|maintenance of protein location in extracellular region|
|sequestering of extracellular ligand from receptor|
|extracellular negative regulation of signal transduction|
|extracellular regulation of signal transduction|
|transforming growth factor beta binding|
|macrophage differentiation|
|superoxide metabolic process|
|myeloid cell development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|transforming growth factor beta receptor signaling pathway|
|maintenance of protein location|
|glial cell development|
|myeloid leukocyte differentiation|
|reactive oxygen species metabolic process|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of cellular response to growth factor stimulus|
|cytokine production|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|maintenance of location|
|protein localization to extracellular region|
|glial cell differentiation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|gliogenesis|
|myeloid cell differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|leukocyte differentiation|
|inflammatory response|
|cellular response to growth factor stimulus|
|response to growth factor|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|immune system development|
|enzyme linked receptor protein signaling pathway|
|innate immune response|
|endoplasmic reticulum membrane|
|defense response to other organism|
|central nervous system development|
|endoplasmic reticulum|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.1|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6747
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NRROS Expression in NALM6 Cells: 4.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>