NRROS

Gene Information

Official Symbol: NRROS
Official Name: negative regulator of reactive oxygen species
Aliases and Previous Symbols: N/A
Entrez ID: 375387
UniProt: Q86YC3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. {ECO:0000250, ECO:0000269|PubMed:23545260}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6747
Expression level (log2 read counts): 4.09

Expression Distribution

Screen	Score
Nicotinamide 1000μM R03 exp101	-2.1
Pyronaridine 1μM R06 exp295	-1.89

transforming growth factor beta1 activation
transforming growth factor beta1 production
transforming growth factor beta production
transforming growth factor beta activation
microglia differentiation
sequestering of TGFbeta in extracellular matrix
microglia development
maintenance of protein location in extracellular region
sequestering of extracellular ligand from receptor
extracellular negative regulation of signal transduction
extracellular regulation of signal transduction
transforming growth factor beta binding
macrophage differentiation
superoxide metabolic process
myeloid cell development
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
transforming growth factor beta receptor signaling pathway
maintenance of protein location
glial cell development
myeloid leukocyte differentiation
reactive oxygen species metabolic process
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of cellular response to growth factor stimulus
cytokine production
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
maintenance of location
protein localization to extracellular region
glial cell differentiation
transmembrane receptor protein serine/threonine kinase signaling pathway
gliogenesis
myeloid cell differentiation
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
leukocyte differentiation
inflammatory response
cellular response to growth factor stimulus