NRXN2

Entrez Summary: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).[provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Laminin G 1
Laminin G 2

gephyrin clustering involved in postsynaptic density assembly
neuroligin clustering involved in postsynaptic membrane assembly
neuroligin family protein binding
postsynaptic density protein 95 clustering
postsynaptic density assembly
vocal learning
imitative learning
observational learning
postsynaptic specialization assembly
learned vocalization behavior or vocal learning
postsynaptic membrane assembly
auditory behavior
excitatory synapse assembly
mechanosensory behavior
neuron cell-cell adhesion
postsynaptic density organization
vocalization behavior
postsynaptic specialization organization
postsynapse assembly
response to auditory stimulus
postsynaptic membrane organization
membrane assembly
calcium channel regulator activity
membrane biogenesis
receptor clustering
social behavior
intraspecies interaction between organisms
cell adhesion molecule binding
protein localization to synapse
multi-organism behavior
localization within membrane
postsynapse organization
synapse assembly
presynapse
signal release from synapse
neurotransmitter secretion
transmembrane signaling receptor activity
adult behavior
learning
signal release