NSMF [The Human Chemical-Genetic Interaction Map Project]

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======= NSMF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSMF
  * **<color #00a2e8>Official Name</color>**: NMDA receptor synaptonuclear signaling and neuronal migration factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26012|26012]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6X4W1|Q6X4W1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSMF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSMF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608137|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to electrical stimulus|
|apical dendrite|
|positive regulation of neuron migration|
|cellular response to gonadotropin stimulus|
|cortical cytoskeleton|
|response to gonadotropin|
|nuclear euchromatin|
|regulation of neuron migration|
|response to electrical stimulus|
|positive regulation of protein dephosphorylation|
|regulation of neuronal synaptic plasticity|
|positive regulation of dephosphorylation|
|calcium-dependent protein binding|
|cellular response to amino acid stimulus|
|regulation of dendrite morphogenesis|
|nuclear matrix|
|response to amino acid|
|perikaryon|
|regulation of protein dephosphorylation|
|regulation of dendrite development|
|nuclear envelope|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|regulation of neuron apoptotic process|
|cellular response to acid chemical|
|regulation of dephosphorylation|
|nuclear membrane|
|postsynaptic density|
|synapse|
|regulation of cell morphogenesis involved in differentiation|
|regulation of neuron death|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|neuron projection|
|response to acid chemical|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|cell junction|
|positive regulation of locomotion|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of cell migration|
|response to hormone|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.71|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.74|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7390
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSMF Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>