NSMF

Official Symbol: NSMF
Official Name: NMDA receptor synaptonuclear signaling and neuronal migration factor
Aliases and Previous Symbols: N/A
Entrez ID: 26012
UniProt: Q6X4W1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.71
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.74
AICAR 240μM R05 exp211	1.79

cellular response to electrical stimulus
apical dendrite
positive regulation of neuron migration
cellular response to gonadotropin stimulus
cortical cytoskeleton
response to gonadotropin
nuclear euchromatin
regulation of neuron migration
response to electrical stimulus
positive regulation of protein dephosphorylation
regulation of neuronal synaptic plasticity
positive regulation of dephosphorylation
calcium-dependent protein binding
cellular response to amino acid stimulus
regulation of dendrite morphogenesis
nuclear matrix
response to amino acid
perikaryon
regulation of protein dephosphorylation
regulation of dendrite development
nuclear envelope
regulation of synaptic plasticity
postsynaptic membrane
regulation of neuron apoptotic process
cellular response to acid chemical
regulation of dephosphorylation
nuclear membrane
postsynaptic density
synapse
regulation of cell morphogenesis involved in differentiation
regulation of neuron death
cellular response to abiotic stimulus
cellular response to environmental stimulus
neuron projection
response to acid chemical
dendrite
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
positive regulation of neurogenesis
regulation of cell morphogenesis