NSUN2 [The Human Chemical-Genetic Interaction Map Project]

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======= NSUN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NSUN2
  * **<color #00a2e8>Official Name</color>**: NOP2/Sun RNA methyltransferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54888|54888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08J23|Q08J23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NSUN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NSUN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610916|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nol1 Nop2 Fmu|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA (cytosine-5-)-methyltransferase activity|
|hair follicle maturation|
|meiotic cell cycle checkpoint|
|chromatoid body|
|tRNA methylation|
|methyltransferase activity|
|tRNA binding|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|RNA methylation|
|tRNA modification|
|molting cycle|
|hair cycle|
|spindle|
|tRNA processing|
|anatomical structure maturation|
|spermatid development|
|spermatid differentiation|
|meiotic cell cycle process|
|RNA modification|
|tRNA metabolic process|
|cell cycle checkpoint|
|meiotic cell cycle|
|developmental maturation|
|macromolecule methylation|
|germ cell development|
|methylation|
|cellular process involved in reproduction in multicellular organism|
|in utero embryonic development|
|skin development|
|ncRNA processing|
|epidermis development|
|ncRNA metabolic process|
|cell division|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|RNA processing|
|embryo development|
|multi-organism reproductive process|
|cell cycle process|
|epithelium development|
|regulation of cell cycle|
|cell cycle|
|RNA binding|
|reproductive process|
|reproduction|
|cell development|
|RNA metabolic process|
|tissue development|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.75|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.74|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.77|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.79|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.83|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.85|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.85|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.93|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.09|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.14|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.26|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|3.17|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slfn11|SLFN11]]|0.608|
|[[:human genes:g:gfm1|GFM1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3379
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NSUN2 Expression in NALM6 Cells: 7.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>