NT5M

Gene Information

Official Symbol: NT5M
Official Name: 5',3'-nucleotidase, mitochondrial
Aliases and Previous Symbols: N/A
Entrez ID: 56953
UniProt: Q9NPB1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. {ECO:0000269|PubMed:10899995}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10479
Expression level (log2 read counts): 1.94

Expression Distribution

pyrimidine nucleoside monophosphate catabolic process
pyrimidine deoxyribonucleoside monophosphate catabolic process
dUMP catabolic process
deoxyribonucleoside monophosphate catabolic process
nucleotidase activity
dUMP metabolic process
pyrimidine deoxyribonucleoside monophosphate metabolic process
nucleoside monophosphate catabolic process
pyrimidine deoxyribonucleotide catabolic process
deoxyribonucleoside monophosphate metabolic process
5-nucleotidase activity
pyrimidine nucleotide catabolic process
pyrimidine nucleoside monophosphate metabolic process
pyrimidine deoxyribonucleotide metabolic process
deoxyribonucleotide catabolic process
deoxyribose phosphate catabolic process
pyrimidine nucleoside catabolic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
nucleoside catabolic process
pyrimidine nucleoside metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
nucleotide binding
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside monophosphate metabolic process
nucleobase-containing small molecule biosynthetic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
organophosphate catabolic process
glycosyl compound metabolic process
carbohydrate derivative catabolic process
DNA replication
dephosphorylation
mitochondrial matrix
nucleobase-containing compound catabolic process