NTHL1

Gene Information

Official Symbol: NTHL1
Official Name: nth like DNA glycosylase 1
Aliases and Previous Symbols: N/A
Entrez ID: 4913
UniProt: P78549
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16097
Expression level (log2 read counts): 4.11

Expression Distribution

HhH-GPD
HHH

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
oxidized purine nucleobase lesion DNA N-glycosylase activity
depyrimidination
base-excision repair, AP site formation
DNA N-glycosylase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNA-(apurinic or apyrimidinic site) endonuclease activity
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleotide catabolic process
deoxyribonucleotide catabolic process
pyrimidine deoxyribonucleotide metabolic process
deoxyribose phosphate catabolic process
2-deoxyribonucleotide metabolic process
deoxyribose phosphate metabolic process
deoxyribonucleotide metabolic process
nucleotide-excision repair, DNA incision, 5-to lesion
endonuclease activity
base-excision repair
nucleotide-excision repair, DNA incision
4 iron, 4 sulfur cluster binding
pyrimidine-containing compound catabolic process
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
DNA modification
double-stranded DNA binding
pyrimidine-containing compound metabolic process
nucleobase-containing small molecule biosynthetic process
nucleotide-excision repair
organophosphate catabolic process
carbohydrate derivative catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
DNA repair