NUDT11 [The Human Chemical-Genetic Interaction Map Project]

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======= NUDT11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDT11
  * **<color #00a2e8>Official Name</color>**: nudix hydrolase 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55190|55190]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96G61|Q96G61]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDT11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDT11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300528|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:12105228}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUDIX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diadenosine pentaphosphate metabolic process|
|diadenosine hexaphosphate catabolic process|
|adenosine 5-(hexahydrogen pentaphosphate) metabolic process|
|diphosphoinositol polyphosphate metabolic process|
|diadenosine pentaphosphate catabolic process|
|bis(5-adenosyl)-pentaphosphatase activity|
|diadenosine polyphosphate catabolic process|
|endopolyphosphatase activity|
|diadenosine hexaphosphate metabolic process|
|bis(5-adenosyl)-hexaphosphatase activity|
|adenosine 5-(hexahydrogen pentaphosphate) catabolic process|
|inositol diphosphate tetrakisphosphate diphosphatase activity|
|inositol diphosphate pentakisphosphate diphosphatase activity|
|diphosphoinositol-polyphosphate diphosphatase activity|
|diadenosine polyphosphate metabolic process|
|m7G(5)pppN diphosphatase activity|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|purine nucleotide catabolic process|
|purine-containing compound catabolic process|
|inositol phosphate metabolic process|
|nucleotide catabolic process|
|nucleoside phosphate catabolic process|
|intracellular|
|nucleobase-containing small molecule biosynthetic process|
|polyol metabolic process|
|organophosphate catabolic process|
|carbohydrate derivative catabolic process|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-3.87|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.97|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.89|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.76|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.78|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.93|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.94|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|2|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.01|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.11|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.18|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.18|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.507|
|[[:human genes:p:ppip5k2|PPIP5K2]]|0.487|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10767
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDT11 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>