NUDT11

Gene Information

Official Symbol: NUDT11
Official Name: nudix hydrolase 11
Aliases and Previous Symbols: N/A
Entrez ID: 55190
UniProt: Q96G61
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:12105228}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Arsenate 40μM R06 exp264	-3.87
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.97
Nicotinate 1000μM R03 exp140	-1.89
Hydroxychloroquine 30μM R08 exp490	1.76
Rotenone 20μM R00 exp34	1.78
Pimelic-diphenylamide-106 5μM R00 exp28	1.93
Curcumin 6.5μM R06 exp277	1.94
Dihydrosphingosine 8μM R08 exp476	2
Thimerosal 0.85μM R08 exp529	2.01
Olaparib 4μM R08 exp512	2.11
QNZ 0.01μM R05 exp241	2.18
VE-822 0.04μM R06 exp300	2.18
Artemisinin 50μM R08 exp450	2.54

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10767
Expression level (log2 read counts): 5.17

Expression Distribution

Gene	Correlation
HARS	0.507
PPIP5K2	0.487

diadenosine pentaphosphate metabolic process
diadenosine hexaphosphate catabolic process
adenosine 5-(hexahydrogen pentaphosphate) metabolic process
diphosphoinositol polyphosphate metabolic process
diadenosine pentaphosphate catabolic process
bis(5-adenosyl)-pentaphosphatase activity
diadenosine polyphosphate catabolic process
endopolyphosphatase activity
diadenosine hexaphosphate metabolic process
bis(5-adenosyl)-hexaphosphatase activity
adenosine 5-(hexahydrogen pentaphosphate) catabolic process
inositol diphosphate tetrakisphosphate diphosphatase activity
inositol diphosphate pentakisphosphate diphosphatase activity
diphosphoinositol-polyphosphate diphosphatase activity
diadenosine polyphosphate metabolic process
m7G(5)pppN diphosphatase activity
purine ribonucleotide catabolic process
ribonucleotide catabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
inositol phosphate metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
intracellular
nucleobase-containing small molecule biosynthetic process
polyol metabolic process
organophosphate catabolic process
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process