NUDT14

Entrez Summary: N/A
UniProt Summary: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

UDP-sugar diphosphatase activity
ADP-ribose diphosphatase activity
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
protein N-linked glycosylation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
ribose phosphate metabolic process
glycoprotein metabolic process
nucleoside phosphate metabolic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
peptidyl-amino acid modification
organophosphate metabolic process
carbohydrate derivative metabolic process
identical protein binding
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process