NUDT4

Gene Information

Official Symbol: NUDT4
Official Name: nudix hydrolase 4
Aliases and Previous Symbols: N/A
Entrez ID: 11163
UniProt: Q9NZJ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 3355
Expression level (log2 read counts): 7.01

Expression Distribution

diadenosine pentaphosphate metabolic process
diadenosine hexaphosphate catabolic process
adenosine 5-(hexahydrogen pentaphosphate) metabolic process
diphosphoinositol polyphosphate metabolic process
diadenosine pentaphosphate catabolic process
diadenosine polyphosphate catabolic process
bis(5-adenosyl)-pentaphosphatase activity
endopolyphosphatase activity
diadenosine hexaphosphate metabolic process
bis(5-adenosyl)-hexaphosphatase activity
adenosine 5-(hexahydrogen pentaphosphate) catabolic process
inositol diphosphate tetrakisphosphate diphosphatase activity
inositol diphosphate pentakisphosphate diphosphatase activity
diphosphoinositol-polyphosphate diphosphatase activity
diadenosine polyphosphate metabolic process
m7G(5)pppN diphosphatase activity
snoRNA binding
purine ribonucleotide catabolic process
ribonucleotide catabolic process
purine nucleotide catabolic process
purine-containing compound catabolic process
inositol phosphate metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleobase-containing small molecule biosynthetic process
polyol metabolic process
organophosphate catabolic process
calcium-mediated signaling
cyclic-nucleotide-mediated signaling
carbohydrate derivative catabolic process
purine ribonucleotide metabolic process
alcohol metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
second-messenger-mediated signaling
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process