NUGGC

Entrez Summary: N/A
UniProt Summary: Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA (PubMed:19734146). Reduces somatic hypermutation in B-cells which may enhance genome stability (By similarity). {ECO:0000250|UniProtKB:D3YWJ0, ECO:0000269|PubMed:19734146}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of nuclear cell cycle DNA replication
regulation of DNA-dependent DNA replication
regulation of DNA replication
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
cellular response to biotic stimulus
response to lipopolysaccharide
response to molecule of bacterial origin
GTPase activity
GTP binding
nuclear speck
cellular response to lipid
response to bacterium
regulation of cell cycle process
response to lipid
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
cellular response to oxygen-containing compound
regulation of cell cycle
response to other organism
response to external biotic stimulus
response to biotic stimulus
regulation of apoptotic process
response to oxygen-containing compound
regulation of programmed cell death
regulation of cell death