OARD1

Entrez Summary: N/A
UniProt Summary: Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O- acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP- ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
MK-1775 0.32μM R02 exp75	1.75
Prochlorperazine 5.2μM R02 exp77	1.8

O-acetyl-ADP-ribose deacetylase activity
purine nucleoside binding
ADP-ribosylglutamate hydrolase activity
peptidyl-glutamate ADP-deribosylation
protein de-ADP-ribosylation
site of DNA damage
purine nucleoside metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
purine-containing compound metabolic process
nucleobase-containing small molecule metabolic process
cellular response to DNA damage stimulus
nucleolus
carbohydrate derivative metabolic process
cellular response to stress
small molecule metabolic process