OASL

Entrez Summary: N/A
UniProt Summary: Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559, ECO:0000269|PubMed:9826176}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

2-5-oligoadenylate synthetase activity
regulation of ribonuclease activity
regulation of nuclease activity
thyroid hormone receptor binding
negative regulation of viral genome replication
cellular response to type I interferon
type I interferon signaling pathway
response to type I interferon
double-stranded RNA binding
interferon-gamma-mediated signaling pathway
negative regulation of viral life cycle
regulation of viral genome replication
negative regulation of viral process
regulation of viral life cycle
cellular response to interferon-gamma
response to interferon-gamma
defense response to virus
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
response to virus
cytokine-mediated signaling pathway
innate immune response
regulation of multi-organism process
nucleolus
defense response to other organism
cellular response to cytokine stimulus
immune effector process
response to cytokine
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
RNA binding
DNA binding
ATP binding
immune response
membrane