OAT [The Human Chemical-Genetic Interaction Map Project]

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======= OAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OAT
  * **<color #00a2e8>Official Name</color>**: ornithine aminotransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4942|4942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04181|P04181]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613349|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|arginine catabolic process to glutamate|
|ornithine-oxo-acid transaminase activity|
|arginine catabolic process to proline|
|arginine catabolic process to proline via ornithine|
|proline biosynthetic process|
|L-proline biosynthetic process|
|arginine catabolic process|
|proline metabolic process|
|protein hexamerization|
|arginine metabolic process|
|glutamine family amino acid biosynthetic process|
|glutamine family amino acid catabolic process|
|glutamate metabolic process|
|pyridoxal phosphate binding|
|alpha-amino acid biosynthetic process|
|glutamine family amino acid metabolic process|
|cellular amino acid biosynthetic process|
|dicarboxylic acid metabolic process|
|alpha-amino acid catabolic process|
|cellular amino acid catabolic process|
|alpha-amino acid metabolic process|
|visual perception|
|sensory perception of light stimulus|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|small molecule catabolic process|
|drug metabolic process|
|protein complex oligomerization|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|sensory perception|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|heterocycle biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|nervous system process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.3|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.06|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.76|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18512
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OAT Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>