OAT

Entrez Summary: This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

arginine catabolic process to glutamate
ornithine-oxo-acid transaminase activity
arginine catabolic process to proline
arginine catabolic process to proline via ornithine
proline biosynthetic process
L-proline biosynthetic process
arginine catabolic process
proline metabolic process
protein hexamerization
arginine metabolic process
glutamine family amino acid biosynthetic process
glutamine family amino acid catabolic process
glutamate metabolic process
pyridoxal phosphate binding
alpha-amino acid biosynthetic process
glutamine family amino acid metabolic process
cellular amino acid biosynthetic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
alpha-amino acid metabolic process
visual perception
sensory perception of light stimulus
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
mitochondrial matrix
small molecule catabolic process
drug metabolic process
protein complex oligomerization
small molecule biosynthetic process
carboxylic acid metabolic process
sensory perception
oxoacid metabolic process
organic acid metabolic process
organonitrogen compound catabolic process
heterocycle biosynthetic process
mitochondrion