OAZ2

Gene Information

Official Symbol: OAZ2
Official Name: ornithine decarboxylase antizyme 2
Aliases and Previous Symbols: N/A
Entrez ID: 4947
UniProt: O95190
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). {ECO:0000250|UniProtKB:O08608, ECO:0000269|PubMed:17900240}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7415
Expression level (log2 read counts): 5.68

Expression Distribution

negative regulation of polyamine transmembrane transport
ornithine decarboxylase inhibitor activity
regulation of polyamine transmembrane transport
polyamine biosynthetic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
regulation of cellular amino acid metabolic process
amine metabolic process
regulation of cellular amine metabolic process
negative regulation of transmembrane transport
positive regulation of intracellular protein transport
regulation of cellular ketone metabolic process
positive regulation of intracellular transport
positive regulation of protein catabolic process
regulation of intracellular protein transport
positive regulation of cellular protein localization
regulation of intracellular transport
regulation of protein catabolic process
positive regulation of protein transport
regulation of small molecule metabolic process
positive regulation of catabolic process
positive regulation of establishment of protein localization
negative regulation of transport
regulation of cellular protein localization
regulation of transmembrane transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
negative regulation of catalytic activity
regulation of cellular localization
positive regulation of transport
regulation of catabolic process
regulation of protein localization
negative regulation of molecular function
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
positive regulation of protein metabolic process