ODAM

Entrez Summary: N/A
UniProt Summary: Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. {ECO:0000269|PubMed:25911094}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

supramolecular fiber
positive regulation of epithelial cell proliferation involved in wound healing
cell periphery
odontogenesis of dentin-containing tooth
biomineralization
biomineral tissue development
odontogenesis
positive regulation of epithelial cell proliferation
regulation of epithelial cell proliferation
regulation of actin cytoskeleton organization
regulation of actin filament-based process
positive regulation of GTPase activity
wound healing
regulation of GTPase activity
inflammatory response
regulation of cytoskeleton organization
response to wounding
positive regulation of hydrolase activity
positive regulation of cell population proliferation
animal organ morphogenesis
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
regulation of hydrolase activity
regulation of organelle organization
defense response
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
extracellular space
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of protein metabolic process
tissue development
positive regulation of molecular function
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process