OGDHL

Entrez Summary: The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. [provided by RefSeq, Dec 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Transket pyr
E1 dh

oxoglutarate dehydrogenase (succinyl-transferring) activity
thiamine pyrophosphate binding
oxoglutarate dehydrogenase complex
tricarboxylic acid cycle
glycolytic process
ATP generation from ADP
ADP metabolic process
nucleoside diphosphate phosphorylation
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
aerobic respiration
nucleoside diphosphate metabolic process
carbohydrate catabolic process
cellular respiration
ATP metabolic process
energy derivation by oxidation of organic compounds
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
mitochondrial matrix
generation of precursor metabolites and energy
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
organophosphate metabolic process
carboxylic acid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
mitochondrion
phosphorylation
small molecule metabolic process