OLFM2

Entrez Summary: N/A
UniProt Summary: Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity). {ECO:0000250|UniProtKB:Q568Y7, ECO:0000250|UniProtKB:Q8BM13, ECO:0000269|PubMed:25298399}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Noelin-1
OLF

extrinsic component of synaptic membrane
regulation of vascular smooth muscle cell dedifferentiation
regulation of phenotypic switching
positive regulation of smooth muscle cell differentiation
AMPA glutamate receptor complex
regulation of smooth muscle cell differentiation
positive regulation of muscle cell differentiation
regulation of muscle cell differentiation
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
peptide secretion
locomotory behavior
visual perception
sensory perception of light stimulus
glutamatergic synapse
cell junction
behavior
positive regulation of cell differentiation
sensory perception
secretion by cell
export from cell
secretion
positive regulation of developmental process
nervous system process
protein transport
peptide transport
amide transport
establishment of protein localization
regulation of cell differentiation
nitrogen compound transport
extracellular region
system process