OLFM4 [The Human Chemical-Genetic Interaction Map Project]

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======= OLFM4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OLFM4
  * **<color #00a2e8>Official Name</color>**: olfactomedin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10562|10562]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UX06|Q6UX06]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OLFM4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OLFM4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614061|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. {ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OLF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of neutrophil extravasation|
|azurophil granule|
|specific granule|
|regulation of cellular extravasation|
|regulation of necrotic cell death|
|regulation of neutrophil migration|
|positive regulation of substrate adhesion-dependent cell spreading|
|catalytic activity|
|regulation of substrate adhesion-dependent cell spreading|
|tertiary granule lumen|
|specific granule lumen|
|secretory granule|
|regulation of phagocytosis|
|positive regulation of cell-substrate adhesion|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of leukocyte migration|
|regulation of cell-substrate adhesion|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|protein homooligomerization|
|positive regulation of cell adhesion|
|neutrophil degranulation|
|regulation of cell morphogenesis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of cellular component organization|
|mitochondrion|
|positive regulation of developmental process|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|regulation of immune system process|
|regulation of cell death|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15608
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OLFM4 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>