OLFM4

Entrez Summary: N/A
UniProt Summary: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. {ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:17270022, ECO:0000269|PubMed:20724538}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of neutrophil extravasation
azurophil granule
specific granule
regulation of cellular extravasation
regulation of necrotic cell death
regulation of neutrophil migration
positive regulation of substrate adhesion-dependent cell spreading
catalytic activity
regulation of substrate adhesion-dependent cell spreading
tertiary granule lumen
specific granule lumen
secretory granule
regulation of phagocytosis
positive regulation of cell-substrate adhesion
positive regulation of cell morphogenesis involved in differentiation
regulation of leukocyte migration
regulation of cell-substrate adhesion
regulation of cell morphogenesis involved in differentiation
cadherin binding
protein homooligomerization
positive regulation of cell adhesion
neutrophil degranulation
regulation of cell morphogenesis
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
protein complex oligomerization
myeloid cell activation involved in immune response
positive regulation of cell development
regulation of vesicle-mediated transport
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulation of cell adhesion
perinuclear region of cytoplasm
regulated exocytosis
leukocyte mediated immunity