OLIG3

Entrez Summary: N/A
UniProt Summary: May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Methotrexate 0.01μM R08 exp501	1.75
Pyrazinamide 100μM R08 exp516	1.86

spinal cord motor neuron migration
motor neuron migration
spinal cord motor neuron cell fate specification
neuron fate specification
spinal cord motor neuron differentiation
ventral spinal cord development
cell differentiation in spinal cord
neuron fate commitment
cell fate specification
spinal cord development
neuron migration
protein dimerization activity
central nervous system neuron differentiation
transcription corepressor activity
cell fate commitment
negative regulation of transcription by RNA polymerase II
cell migration
central nervous system development
neuron differentiation
cell motility
localization of cell
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
locomotion
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
negative regulation of biosynthetic process
movement of cell or subcellular component
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
negative regulation of gene expression