ONECUT1

Gene Information

Official Symbol: ONECUT1
Official Name: one cut homeobox 1
Aliases and Previous Symbols: N/A
Entrez ID: 3175
UniProt: Q9UBC0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10628
Expression level (log2 read counts): 2.31

Expression Distribution

Homeobox
CUT

spleen development
endocrine pancreas development
pancreas development
negative regulation of transforming growth factor beta receptor signaling pathway
endoderm development
negative regulation of cellular response to transforming growth factor beta stimulus
B cell differentiation
glucose metabolic process
regulation of transforming growth factor beta receptor signaling pathway
regulation of cell-matrix adhesion
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
endocrine system development
liver development
Notch signaling pathway
hepaticobiliary system development
negative regulation of cellular response to growth factor stimulus
B cell activation
hexose metabolic process
epithelial cell development
monosaccharide metabolic process
regulation of cell-substrate adhesion
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
lymphocyte differentiation
cell fate commitment
regulation of cellular response to growth factor stimulus
leukocyte differentiation
cilium assembly
cilium organization
lymphocyte activation
gland development
plasma membrane bounded cell projection assembly
DNA-binding transcription activator activity, RNA polymerase II-specific
cell projection assembly
carbohydrate metabolic process
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
hemopoiesis