OPRD1

Entrez Summary: N/A
UniProt Summary: G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

enkephalin receptor activity
spine apparatus
neuronal dense core vesicle
receptor serine/threonine kinase binding
opioid receptor activity
opioid receptor signaling pathway
negative regulation of protein oligomerization
positive regulation of CREB transcription factor activity
neuropeptide binding
eating behavior
dendrite membrane
integral component of synaptic vesicle membrane
intrinsic component of plasma membrane
regulation of sensory perception of pain
regulation of sensory perception
regulation of protein oligomerization
integral component of postsynaptic density membrane
peptide binding
axon terminus
integral component of presynaptic membrane
regulation of mitochondrial membrane potential
adult locomotory behavior
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
feeding behavior
phospholipase C-activating G protein-coupled receptor signaling pathway
positive regulation of peptidyl-serine phosphorylation
neuropeptide signaling pathway
negative regulation of protein complex assembly
regulation of peptidyl-serine phosphorylation
regulation of nervous system process
adult behavior
cellular response to hypoxia
locomotory behavior
cellular response to decreased oxygen levels
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cellular response to toxic substance
cellular response to oxygen levels
membrane raft
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of calcium ion transport