ORM2

Gene Information

Official Symbol: ORM2
Official Name: orosomucoid 2
Aliases and Previous Symbols: N/A
Entrez ID: 5005
UniProt: P19652
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction. {ECO:0000269|PubMed:21349832}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17028
Expression level (log2 read counts): -3.28

Expression Distribution

positive regulation of tumor necrosis factor secretion
regulation of tumor necrosis factor secretion
positive regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 secretion
acute-phase response
regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta production
regulation of interleukin-1 secretion
positive regulation of interleukin-1 production
specific granule lumen
platelet alpha granule lumen
acute inflammatory response
regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
azurophil granule lumen
regulation of interleukin-1 production
platelet degranulation
positive regulation of cytokine secretion
blood microparticle
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
regulation of cytokine secretion
positive regulation of protein secretion
positive regulation of peptide secretion
collagen-containing extracellular matrix
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of cytokine production
positive regulation of establishment of protein localization
regulation of protein secretion
neutrophil degranulation
neutrophil activation involved in immune response
regulation of peptide secretion
neutrophil mediated immunity
inflammatory response
neutrophil activation
granulocyte activation
leukocyte degranulation